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RGD ID: 2623
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fmr1
Name: fragile X mental retardation 1
Acc ID: CHEBI:64159
Term: 2-methyl-6-(phenylethynyl)pyridine
Definition: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Chemical ID: MESH:C121465
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Potassium Chloride affects the localization of FMR1 protein]

multiple interactionsISORGD:7359206480464CTDFMR1 gene mutant form promotes the reaction [6-methyl-2-(phenylethynyl)pyridine binds to GRM5 protein]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.