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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309512
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gopc
Name: golgi associated PDZ and coiled-coil motif containing
Acc ID: CHEBI:64159
Term: 2-methyl-6-(phenylethynyl)pyridine
Definition: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Chemical ID: MESH:C121465
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gopcmultiple interactionsEXP 6480464CTD6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]PMID:33571554
Gopcmultiple interactionsISOGopc (Mus musculus)6480464CTD6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of AKT1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the phosphorylation of MAPK8 protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [Oxidopamine affects the expression of GOPC protein]; GOPC protein affects the reaction [6-methyl-2-(phenylethynyl)pyridine promotes the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]PMID:33571554
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