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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732369
Species: Mus musculus
RGD Object: Gene
Symbol: Ntf3
Name: neurotrophin 3
Acc ID: CHEBI:64156
Term: imetit
Definition: An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Chemical ID: MESH:C077430
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntf3increases expressionISONtf3 (Rattus norvegicus)6480464CTDimetit results in increased expression of NTF3 proteinPMID:21276809
Ntf3multiple interactionsISONtf3 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imetit results in increased expression of NTF3 protein]; [methylhistaprodifen co-treated with Dimaprit co-treated with imetit] results in increased expression of NTF3 protein; Pertussis Toxin inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [imetit results in increased expression of NTF3 protein]PMID:21276809
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