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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDLetrozole results in decreased expression of CYP17A1 mRNAPMID:37254606
Cyp17a1increases expressionEXP 6480464CTDLetrozole results in increased expression of CYP17A1 mRNAPMID:37030623
Cyp17a1multiple interactionsEXP 6480464CTD[Letrozole co-treated with tris(2,3-dibromopropyl)isocyanurate] results in decreased expression of CYP17A1 mRNA; diacerein inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]PMID:37030623 PMID:37254606
Cyp17a1increases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDLetrozole results in increased expression of CYP17A1 mRNAPMID:32298659
Cyp17a1multiple interactionsISOCyp17a1 (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]; Niacinamide inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]PMID:32298659
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