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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:64108
Term: 8-bromo-3',5'-cyclic GMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Chemical ID: MESH:C016276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTD8-bromocyclic GMP results in increased expression of PPARGC1A mRNAPMID:24041027
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTDtin protoporphyrin IX inhibits the reaction [8-bromocyclic GMP results in increased expression of PPARGC1A mRNA]PMID:24041027
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