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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734248
Species: Mus musculus
RGD Object: Gene
Symbol: Eef1a2
Name: eukaryotic translation elongation factor 1 alpha 2
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eef1a2increases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 proteinPMID:26558463
Eef1a2increases expressionISOEEF1A2 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 proteinPMID:37051183
Eef1a2multiple interactionsISOEEF1A2 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium affects the reaction [EEF1A2 protein affects the cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 protein]; [EEF1A2 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the cleavage of CASP3 protein; [EEF1A2 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the expression of CASP3 mRNA; [EEF1A2 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium] which affects the expression of TP53 mRNA; [Wortmannin co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of EEF1A2 protein; EEF1A2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; EEF1A2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; EEF1A2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MTOR protein]PMID:35594436 PMID:37051183
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