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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731644
Species: Homo sapiens
RGD Object: Gene
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RPS6KB1decreases phosphorylationEXP 6480464CTD1-Methyl-4-phenylpyridinium results in decreased phosphorylation of RPS6KB1 proteinPMID:25017139
RPS6KB1decreases phosphorylationISORps6kb1 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in decreased phosphorylation of RPS6KB1 proteinPMID:25680463
RPS6KB1decreases response to substanceISORps6kb1 (Mus musculus)6480464CTDRPS6KB1 protein modified form results in decreased susceptibility to 1-Methyl-4-phenylpyridiniumPMID:25680463
RPS6KB1multiple interactionsISORps6kb1 (Mus musculus)6480464CTD[ULK1 protein results in decreased phosphorylation of RPS6KB1 protein] which results in increased susceptibility to 1-Methyl-4-phenylpyridinium; ULK1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of RPS6KB1 protein]PMID:25680463
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