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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731380
Species: Homo sapiens
RGD Object: Gene
Symbol: AIFM1
Name: apoptosis inducing factor mitochondria associated 1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AIFM1affects localizationEXP 6480464CTD1-Methyl-4-phenylpyridinium affects the localization of AIFM1 proteinPMID:12880480
AIFM1multiple interactionsEXP 6480464CTDSelegiline inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]PMID:12880480
AIFM1affects localizationISOAifm1 (Rattus norvegicus)6480464CTD1-Methyl-4-phenylpyridinium affects the localization of AIFM1 proteinPMID:19466539
AIFM1affects localizationISOAifm1 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium affects the localization of AIFM1 proteinPMID:16860906
AIFM1increases expressionISOAifm1 (Rattus norvegicus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of AIFM1 proteinPMID:31022188 PMID:31376345
AIFM1multiple interactionsISOAifm1 (Rattus norvegicus)6480464CTD[1-Methyl-4-phenylpyridinium results in increased activity of CAPN1 protein] which results in increased localization of AIFM1 protein; KANK2 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of AIFM1 protein]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]; Resveratrol inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]PMID:18496573 PMID:19466539 PMID:31376345
AIFM1multiple interactionsISOAifm1 (Mus musculus)6480464CTDATRN protein affects the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]PMID:16860906
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