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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2increases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 proteinPMID:34481870
PTGS2multiple interactionsEXP 6480464CTDgenkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]]PMID:34481870
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 proteinPMID:31430510
PTGS2increases expressionISOPtgs2 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 mRNAPMID:30686998
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDoridonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]PMID:31430510
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium promotes the reaction [[lipopolysaccharide, E. coli O26-B6 co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]PMID:30686998
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