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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730919
Species: Homo sapiens
RGD Object: Gene
Symbol: RTN4
Name: reticulon 4
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RTN4increases expressionISORtn4 (Rattus norvegicus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of RTN4 proteinPMID:26648565
RTN4multiple interactionsISORtn4 (Rattus norvegicus)6480464CTDRTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MTOR protein]; RTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4R protein]; RTN4 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of STAT3 protein]; Sirolimus inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RTN4 protein]PMID:26648565
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