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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69095
Species: Homo sapiens
RGD Object: Gene
Symbol: TGFB1
Name: transforming growth factor beta 1
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TGFB1decreases response to substanceEXP 6480464CTDTGFB1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridiniumPMID:7882977
TGFB1decreases expressionISOTgfb1 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of TGFB1 mRNAPMID:32606391
TGFB1increases expressionISOTgfb1 (Mus musculus)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of TGFB1 mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of TGFB1 proteinPMID:28268219 PMID:34967706
TGFB1multiple interactionsISOTgfb1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; [IL4 protein co-treated with 1-Methyl-4-phenylpyridinium] affects the expression of TGFB1 mRNA; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 mRNA]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CD40 protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CD86 protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 mRNA]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTPRC protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]PMID:26254549 PMID:32606391
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