Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein

PMID:24140863
increases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA

PMID:28801915
increases methylationEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased methylation of CASP12 gene

PMID:28801915
multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein], TXN protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein]

PMID:24140863
increases expressionISORGD:13480776480464CTD1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA

PMID:25073091
multiple interactionsISORGD:13480776480464CTDchikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA], TXN protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP12 protein]

PMID:24140863, PMID:25073091
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.