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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc7a11
Name: solute carrier family 7 member 11
Acc ID: CHEBI:641
Term: N-methyl-4-phenylpyridinium
Definition: A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position.
Chemical ID: MESH:D015655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc7a11decreases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 proteinPMID:33737050
Slc7a11increases expressionEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of SLC7A11 mRNAPMID:28801915
Slc7a11increases methylationEXP 6480464CTD1-Methyl-4-phenylpyridinium results in increased methylation of SLC7A11 genePMID:28801915
Slc7a11multiple interactionsEXP 6480464CTDferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein]; pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein]PMID:33737050
Slc7a11increases expressionISOSLC7A11 (Homo sapiens)6480464CTD1-Methyl-4-phenylpyridinium results in increased expression of SLC7A11 mRNAPMID:24810058 PMID:32870474
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