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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDGPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:12566075
increases response to substanceEXP 6480464CTDGPX4 gene mutant form results in increased susceptibility to tert-Butylhydroperoxide

PMID:12566075
decreases response to substanceISORGD:7360496480464CTDGPX4 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:15496407
multiple interactionsISORGD:7360496480464CTDGPX4 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]

PMID:15496407
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.