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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDALDH2 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:15003993
increases expressionEXP 6480464CTDtert-Butylhydroperoxide results in increased expression of ALDH2 mRNA

PMID:14729362, PMID:15003993, PMID:15336504
increases expressionISORGD:692206480464CTDtert-Butylhydroperoxide results in increased expression of ALDH2 mRNA

PMID:15336504
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.