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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDtert-Butylhydroperoxide results in increased cleavage of PARP1 proteinPMID:15569404
Parp1multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]PMID:15569404
Parp1decreases expressionISOPARP1 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of PARP1 proteinPMID:28733231
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased cleavage of PARP1 proteinPMID:27050144 PMID:27511913 PMID:29111459
Parp1increases cleavageISOParp1 (Mus musculus)6480464CTDtert-Butylhydroperoxide results in increased cleavage of PARP1 proteinPMID:16753784
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Drugs, Chinese Herbal inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PARP1 protein]; LY96 protein affects the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; nectandrin-B inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]PMID:27050144 PMID:27511913 PMID:28733231 PMID:29111459
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDCatechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]PMID:16753784
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