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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDtert-Butylhydroperoxide results in increased expression of NQO1 mRNAPMID:30547568
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of NQO1 mRNA; tert-Butylhydroperoxide results in decreased expression of NQO1 proteinPMID:28025122 PMID:30273691
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased expression of NQO1 mRNAPMID:12414654 PMID:35077135
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDrutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein]; sodium boranocarbonate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 mRNA]PMID:28025122 PMID:30273691
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