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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62054
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdyn
Name: prodynorphin
Acc ID: CHEBI:64086
Term: vanoxerine dihydrochloride
Definition: A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Chemical ID: MESH:C043425
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdynaffects expressionEXP 6480464CTDvanoxerine affects the expression of PDYN proteinPMID:14997015
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