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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606589
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C8
Name: cytochrome P450 family 2 subfamily C member 8
Acc ID: CHEBI:64086
Term: vanoxerine dihydrochloride
Definition: A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Chemical ID: MESH:C043425
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C8decreases degradationEXP 6480464CTDCYP2C8 protein results in decreased degradation of vanoxerinePMID:11502731
CYP2C8multiple interactionsEXP 6480464CTD[Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerinePMID:11502731
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