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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2254
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calca
Name: calcitonin-related polypeptide alpha
Acc ID: CHEBI:64053
Term: 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate
Definition: A maleate salt that is the dimaleate salt of 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline. A 5-hydroxytryptamine receptor 1B (5-HT1B) full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Centrally active following systemic administration.
Chemical ID: MESH:C052561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calcadecreases expressionEXP 6480464CTDCGS 12066B results in decreased expression of CALCA mRNA

PMID:14715155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.