GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ATF4 | increases expression | EXP | | 6480464 | CTD | leflunomide results in increased expression of ATF4 protein | PMID:28988120 PMID:29427785 | ATF4 | multiple interactions | EXP | | 6480464 | CTD | 4-phenylbutyric acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]; [Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of ATF4 protein]; Bongkrekic Acid inhibits the reaction [leflunomide results in increased expression of ATF4 protein]; MAPK1 protein affects the reaction [leflunomide results in increased expression of ATF4 protein]; MAPK3 protein affects the reaction [leflunomide results in increased expression of ATF4 protein] | PMID:28988120 PMID:29427785 | ATF4 | increases expression | ISO | Atf4 (Rattus norvegicus) | 6480464 | CTD | leflunomide results in increased expression of ATF4 mRNA | PMID:24136188 | | ||||||||||||||||||||||
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