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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp5mc1
Name: ATP synthase membrane subunit c locus 1
Acc ID: CHEBI:6402
Term: leflunomide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical ID: MESH:C045463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13484206480464CTDleflunomide results in decreased expression of ATP5G1 mRNA, leflunomide results in decreased expression of ATP5MC1 mRNA

PMID:28988120, PMID:29427785
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