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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:6402
Term: leflunomide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical ID: MESH:C045463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107966480464CTDleflunomide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased activity of ARG1 protein], leflunomide inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein], leflunomide promotes the reaction [IL4 protein results in increased expression of TNF mRNA]

PMID:21775527, PMID:26699812
multiple interactionsISORGD:7363066480464CTDleflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]], leflunomide inhibits the reaction [IL4 protein results in increased expression of CCL26 protein]

PMID:16045735, PMID:26091108
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.