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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox15
Name: arachidonate 15-lipoxygenase
Acc ID: CHEBI:64017
Term: (5Z,8Z,11Z,13E)-15-HETE
Definition: A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.
Chemical ID: MESH:C025984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox15increases chemical synthesisEXP 6480464CTDALOX15 protein results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid

PMID:18984061
Alox15multiple interactionsEXP 6480464CTD[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein [Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid cinnamyl-3 4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]

PMID:18984061
Alox15increases abundanceISORGD:13523726480464CTDALOX15 protein results in increased abundance of 15-hydroxy-5 8 11 13-eicosatetraenoic acid

PMID:23872364
Alox15multiple interactionsISORGD:7336266480464CTD[ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 15-hydroxy-5 8 11 13-eicosatetraenoic acid

PMID:21193584
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