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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:63959
Term: celastrol
Definition: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Chemical ID: MESH:C050414
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDcelastrol results in increased expression of HMOX1 mRNAPMID:17010675
HMOX1increases expressionISOHmox1 (Mus musculus)6480464CTDcelastrol results in increased expression of HMOX1 proteinPMID:23942037
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDcelastrol results in increased expression of HMOX1 proteinPMID:26768587
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDcelastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Plant Preparations results in decreased expression of HMOX1 protein]PMID:29643811
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTDcelastrol inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]PMID:26768587 PMID:30588110
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