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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:63959
Term: celastrol
Definition: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
Chemical ID: MESH:C050414
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtripterine results in increased expression of HMOX1 protein

PMID:26768587
multiple interactionsEXP 6480464CTDtripterine inhibits the reaction [Bleomycin results in decreased expression of HMOX1 protein]

PMID:26768587
increases expressionISORGD:107176480464CTDtripterine results in increased expression of HMOX1 protein

PMID:23942037
increases expressionISORGD:7309016480464CTDtripterine results in increased expression of HMOX1 mRNA

PMID:17010675
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.