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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:63952
Term: arsenic trichloride
Definition: A arsenic molecular entity that consists of a single arsenic atom bearing three chloro substituents.
Chemical ID: MESH:C050510
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDarsenic trichloride results in increased phosphorylation of MAPK9 proteinPMID:22696236 PMID:24434654
Mapk9multiple interactionsISOMAPK9 (Homo sapiens)6480464CTDMAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]PMID:22696236 PMID:24434654
Mapk9multiple interactionsISOMapk9 (Mus musculus)6480464CTDMAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]PMID:22696236
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