GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3911
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tshr
Name: thyroid stimulating hormone receptor
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in increased expression of TSHR mRNA

PMID:18178546
decreases activityISORGD:7370216480464CTDChlorodiphenyl (54% Chlorine) results in decreased activity of TSHR protein

PMID:14759065
multiple interactionsISORGD:7370216480464CTDChlorodiphenyl (54% Chlorine) binds to and results in decreased activity of TSHR protein

PMID:17062616
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.