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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3757
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Acc ID: CHEBI:63933
Term: Aroclor 1254
Definition: A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).
Chemical ID: MESH:D020111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDChlorodiphenyl (54% Chlorine) results in decreased expression of SRD5A1 mRNA, Chlorodiphenyl (54% Chlorine) results in decreased expression of SRD5A1 protein

PMID:18178546, PMID:29208485
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.