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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69226
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases activityISORGD:7360496480464CTDArtesunate results in decreased activity of GPX4 protein

PMID:30551460
Gpx4multiple interactionsISORGD:7360506480464CTDArtesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]

PMID:30551460
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