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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTDartesunate inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of MMP9 protein]

PMID:29031619
Mmp9decreases expressionISORGD:13484376480464CTDArtesunate results in decreased expression of MMP9 mRNA

PMID:30551460
Mmp9multiple interactionsISORGD:13484376480464CTDChloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]

PMID:30551460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.