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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1increases phosphorylationISORGD:7322926480464CTDArtesunate results in increased phosphorylation of CHEK1 protein

PMID:31664825
Chek1multiple interactionsISORGD:7322926480464CTDAPOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]

PMID:31664825
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