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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2489
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dbh
Name: dopamine beta-hydroxylase
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dbhincreases response to substanceISORGD:7366596480464CTDDBH mRNA results in increased susceptibility to artesunate

PMID:20144594
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