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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344835
Species: Homo sapiens
RGD Object: Gene
Symbol: ULK1
Name: unc-51 like autophagy activating kinase 1
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ULK1increases phosphorylationEXP 6480464CTDArtesunate results in increased phosphorylation of ULK1 proteinPMID:33002460
ULK1multiple interactionsEXP 6480464CTDacadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]PMID:33002460
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