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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfd2decreases response to substanceISORGD:13227016480464CTDMTHFD2 mRNA results in decreased susceptibility to artesunate

PMID:20144594
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.