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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628896
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Angpt1
Name: angiopoietin 1
Acc ID: CHEBI:63916
Term: iloprost
Definition: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.
Chemical ID: MESH:D016285
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Angpt1increases expressionISORGD:7331366480464CTDIloprost results in increased expression of ANGPT1 mRNA

PMID:16373414
Angpt1multiple interactionsISORGD:7331366480464CTDRTKI cpd inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA]

PMID:16373414
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.