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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:63892
Term: zerumbone
Definition: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
Chemical ID: MESH:C403304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases expressionISOPARP1 (Homo sapiens)6480464CTDzerumbone results in decreased expression of PARP1 mRNAPMID:36122806
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDzerumbone analog results in increased cleavage of PARP1 protein; zerumbone results in increased cleavage of PARP1 proteinPMID:16007145 PMID:28987329
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