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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Acc ID: CHEBI:63836
Term: bromosulfophthalein
Definition: An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1.
Chemical ID: MESH:D013448
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco2b1affects importISOSLCO2B1 (Homo sapiens)6480464CTDSLCO2B1 protein affects the import of SulfobromophthaleinPMID:16046661
Slco2b1decreases activityISOSLCO2B1 (Homo sapiens)6480464CTDSulfobromophthalein results in decreased activity of SLCO2B1 proteinPMID:31364238
Slco2b1increases uptakeISOSLCO2B1 (Homo sapiens)6480464CTDSLCO2B1 protein results in increased uptake of SulfobromophthaleinPMID:21430235 PMID:23121773
Slco2b1multiple interactionsISOSLCO2B1 (Homo sapiens)6480464CTDBudesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]PMID:21430235 PMID:23121773 PMID:25106415 PMID:27450509
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