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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:63804
Term: 4-hydroxyphenytoin
Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing phenyl and 4-hydroxyphenyl substituents at position 5.
Chemical ID: MESH:C001419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a5multiple interactionsISORGD:13435196480464CTDUGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin

PMID:15855726
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.