GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2C9 | increases chemical synthesis | EXP | | 6480464 | CTD | CYP2C9 protein results in increased chemical synthesis of 4'-hydroxytolbutamide; CYP2C9 protein results in increased chemical synthesis of hydroxymethyltolbutamide | PMID:15155557 PMID:21915887 | CYP2C9 | multiple interactions | EXP | | 6480464 | CTD | [CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 4'-hydroxytolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 4'-hydroxytolbutamide] | PMID:21915887 PMID:32198085 | CYP2C9 | multiple interactions | ISO | Cyp2c65 (Mus musculus) | 6480464 | CTD | [CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide | PMID:30503582 | | ||||||||||||||||||||||
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