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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1624096
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Acc ID: CHEBI:6375
Term: lansoprazole
Definition: A sulfoxide that has formula C16H14F3N3O2S.
Chemical ID: MESH:D064747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c38affects metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein affects the metabolism of LansoprazolePMID:15010519
Cyp2c38affects response to substanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene affects the susceptibility to Lansoprazole; CYP2C19 gene polymorphism affects the susceptibility to LansoprazolePMID:11929404 PMID:15963082 PMID:9272410
Cyp2c38decreases activityISOCYP2C19 (Homo sapiens)6480464CTDLansoprazole results in decreased activity of CYP2C19 proteinPMID:21795468
Cyp2c38decreases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 gene polymorphism results in decreased metabolism of LansoprazolePMID:19814645
Cyp2c38increases hydroxylationISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased hydroxylation of LansoprazolePMID:11829200 PMID:12975331 PMID:8627562
Cyp2c38increases metabolic processingISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased metabolism of Lansoprazole; Lansoprazole results in increased metabolism of CYP2C19 proteinPMID:21212520 PMID:8930576
Cyp2c38multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus]; Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]PMID:15010519 PMID:15258107 PMID:15285851 PMID:15963082 PMID:17377957
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