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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:6375
Term: lansoprazole
Definition: A sulfoxide that has formula C16H14F3N3O2S.
Chemical ID: MESH:D064747
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDLansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 proteinPMID:14550749 PMID:25626140 PMID:9152597
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDLansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 proteinPMID:12623754 PMID:8169844 PMID:9744552
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