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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583689
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a5
Name: UDP glucuronosyltransferase family 1 member A5
Acc ID: CHEBI:6367
Term: lamotrigine
Definition: A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
Chemical ID: MESH:C047781
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases glucuronidationISORGD:13435196480464CTDUGT1A4 protein results in increased glucuronidation of lamotrigine

PMID:17151188, PMID:19845433
multiple interactionsISORGD:13435196480464CTD[Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine, [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine, [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine

PMID:19845433
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.