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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2a
Name: DNA topoisomerase II alpha
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2adecreases expressionEXP 6480464CTDTopotecan results in decreased expression of TOP2A mRNAPMID:25729387
Top2amultiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in decreased expression of TOP2A mRNAPMID:25729387
Top2adecreases expressionISOTOP2A (Homo sapiens)6480464CTDTopotecan results in decreased expression of TOP2A mRNAPMID:16026610
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