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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mef2a
Name: myocyte enhancer factor 2a
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTopotecan results in decreased expression of MEF2A mRNA

PMID:25729387
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.