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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320018
Species: Mus musculus
RGD Object: Gene
Symbol: Trex1
Name: three prime repair exonuclease 1
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trex1affects response to substanceISOTREX1 (Homo sapiens)6480464CTDTREX1 affects the susceptibility to TopotecanPMID:23578789
Trex1increases expressionISOTREX1 (Homo sapiens)6480464CTDTopotecan results in increased expression of TREX1 mRNA; Topotecan results in increased expression of TREX1 proteinPMID:23578789
Trex1multiple interactionsISOTrex1 (Rattus norvegicus)6480464CTD[oxaliplatin co-treated with Topotecan] results in increased expression of TREX1 mRNAPMID:25729387
Trex1multiple interactionsISOTREX1 (Homo sapiens)6480464CTDFOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA]; JUN mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA]; Topotecan promotes the reaction [JUN protein binds to TREX1 promoter]PMID:23578789
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