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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10596
Species: Mus musculus
RGD Object: Gene
Symbol: Fos
Name: FBJ osteosarcoma oncogene
Acc ID: CHEBI:63632
Term: topotecan
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Chemical ID: MESH:D019772
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionISOFos (Rattus norvegicus)6480464CTDTopotecan results in increased expression of FOS mRNAPMID:25729387
Fosmultiple interactionsISOFos (Rattus norvegicus)6480464CTD[oxaliplatin co-treated with Topotecan] results in increased expression of FOS mRNAPMID:25729387
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDFOS mutant form inhibits the reaction [Topotecan results in increased expression of TREX1 mRNA]PMID:23578789
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