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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735687
Species: Mus musculus
RGD Object: Gene
Symbol: Grik1
Name: glutamate receptor, ionotropic, kainate 1
Acc ID: CHEBI:63631
Term: topiramate
Definition: A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
Chemical ID: MESH:C052342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grik1affects bindingISOGrik1 (Rattus norvegicus)731146RGDtopiramate binds to Grik1 protein 
Grik1affects response to substanceISOGRIK1 (Homo sapiens)6480464CTDGRIK1 gene SNP affects the susceptibility to topiramatePMID:19331489
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