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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69401
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acsl4
Name: acyl-CoA synthetase long-chain family member 4
Acc ID: CHEBI:63631
Term: topiramate
Definition: A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
Chemical ID: MESH:C052342
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acsl4decreases expressionEXP 6480464CTDtopiramate results in decreased expression of ACSL4 mRNA

PMID:16979414
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