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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:63621
Term: saquinavir
Definition: An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease.
Chemical ID: MESH:D019258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionISOIl6 (Mus musculus)6480464CTDSaquinavir results in increased expression of IL6 mRNA; Saquinavir results in increased expression of IL6 proteinPMID:15865214
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDrosiglitazone inhibits the reaction [Saquinavir results in increased expression of IL6 mRNA]PMID:15865214
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDSaquinavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]PMID:15388451
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